Enzymatic degradation of helodermin and vasoactive intestinal polypeptide.
نویسندگان
چکیده
منابع مشابه
[Vasoactive intestinal polypeptide (V.I.P)].
VIPomas can occur as part of the type 1 multiple endocrine neoplasia (MEN) syndrome. VIP is the principal mediator of the watery diarrhea syndrome (also known as pancreatic cholera, Werner-Morrison syndrome, or diarrheogenic islet cell tumor). Watery diarrhea syndrome, with elevated VIP, has also been associated with neurogenic tumors (ganglioneuroma, neuroblastoma, pheochromocytoma), bronchoge...
متن کاملStructure-activity studies of vasoactive intestinal polypeptide.
This report explores the potential side-chain functional groups required for interaction of the bronchodilator neuropeptide, vasoactive intestinal peptide (VIP), with its receptor. The binding affinity and biological activity of native VIP have been found to be sensitive to the removal of amino- and carboxyl-terminal residues. This data suggests that elements within the entire primary sequence ...
متن کاملVasoactive intestinal polypeptide and pituitary adenylate cyclase-activating polypeptide receptor chimeras reveal domains that determine specificity of vasoactive intestinal polypeptide binding and activation.
Vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) receptors are closely related G protein-coupled receptors with seven-transmembrane domains. The VIP receptor can bind both VIP and PACAP with high affinity, whereas the PACAP receptor binds only PACAP with high affinity. To elucidate the structural domains involved in a selectivity for VIP bin...
متن کاملEffect of an Antagonist of Vasoactive Intestinal Polypeptide on Biological Rhythm of Rest Activity in the Rat
Abstract Vasoactive Intestinal Polypeptide (VIP), has been found in different neurotransmitter systems and exists in various nerve tracts in the brain. Potential role of this peptide in physiological processes such as regulation of sleep and wakefulness, and biological rhythms has been confirmed in several reports. In the present research effects of intracerebroventricular (ICV) injection of a...
متن کاملVasoactive intestinal polypeptide-immunoreactive neurons in rat visual cortex.
An antibody to vasoactive intestinal polypeptide (VIP) was used to examine the forms of VIP-positive neurons and the synapses made by VIP-positive axon terminals. Vasoactive intestinal polypeptide-positive cells are most common in layers II and III and the majority of them are typical bipolar neurons, with two primary dendrites which emanate from the upper and lower poles of the cell body. Thei...
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ژورنال
عنوان ژورنال: Journal of Pharmacobio-Dynamics
سال: 1991
ISSN: 0386-846X,1881-1353
DOI: 10.1248/bpb1978.14.126